Oral Presentation Australasian Extracellular Vesicles Conference 2018

Going through the gut: role of milk extracellular vesicles in cancer progression (#14)

Suresh Mathivanan 1
  1. La Trobe Institute for Molecular Science, Bundoora, VIC, Australia

It has been proposed that exosomes from the diet can be absorbed by the intestinal tract of the consuming organism, be bioavailable in various organs, and exert phenotypic changes. Here, we orally administered bovine milk-derived exosomes to mice and demonstrate that milk-derived exosomes can survive the harsh degrading conditions of the gut and subsequently be detected in multiple organs. Interestingly, oral administration of milk-derived exosomes reduced the primary tumor burden in various cancer models and attenuated cancer cachexia. Intriguingly, in spite of the reduction in primary tumor growth, milk-derived exosomes accelerated metastasis in breast and pancreatic cancer mice models. Timing of exosome administration was critical as oral administration after resection of the primary tumor reversed the pro-metastatic effects of milk-derived exosomes in breast cancer. Taken together, our study provides novel context-based and opposing role of milk-derived exosomes as metastasis inducers and as metastasis blocker.