Oral Presentation Australasian Extracellular Vesicles Conference 2018

Platelet adhesion and aggregation with formation of MVB (#44)

Bruce A Warren 1
  1. self-employed, Coogee, NSW, Australia

When blood platelets change from the transport form i.e. the disc shaped circulating platelet to the activated platelet with dendritic pseudopodia extending from the main body there is the release of multivesicular bodies principally from the pseudopodia. Under certain circumstances (e.g. the administration of an extract of (trimeresurus okinavensis) venom platelets can stick together without developing spiky i.e. dendritic  pseudopodia (Warren and Davey). Publications from last century include:

B.A.Warren and M.G.Davey: Electron microscopy of human platelet aggregates formed in vitro with and without fibrin production. Angiologica 7,84-103,1970

B.A.Warren and A.H.B .De Bono:The ultrastructure of the initial stages of platelet aggregation and adhesion to damaged vessel walls in vitro. British Journal ovf Experimental Pathology 51,415-422,1970.

B.A.Warren: The ultrastructure of platelet pseudopodia and the adhesion of homologous platelets to tumour cells. British Journal of Experimental Pathology 51,570-580,1970.

B.A.Warren:The platelet pseudopodium its involvement in aggregation and adhesion to vessel walls.British Journal of Experimental Pathology 52,378-387,1971.

B.A.Warren and O.Vales:The adhesion of thromboplastic tumour emboli to vessel walls in vivo. British Journal of Experimental Pathology, 53,301-313,1972.

B.A.Warren and O.Vales:The adhesive dendritic pseudopodium of the platelet and the release reaction. Microvascular Research 4,159-178,1972.

B.A.Warren, O.Vales and S.Khan:Platelet pseudopodia and their involvement in adhesion: observations by transmission and scanning electron microscopy. Excerptqa Medica International Congress Series No 357 43-51,1975